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1974 7
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1977 30
1978 40
1979 36
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1984 21
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1987 8
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1993 6
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1995 1
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1998 2
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2000 6
2001 2
2002 1
2003 4
2004 2
2005 6
2006 2
2007 4
2008 5
2009 3
2010 7
2011 5
2012 6
2013 8
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The following term was not found in PubMed: vincamidol
Page 1
Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential.
Ren Y, DeRose K, Li L, Gallucci JC, Yu J, Douglas Kinghorn A. Ren Y, et al. Bioorg Med Chem. 2023 Sep 7;92:117439. doi: 10.1016/j.bmc.2023.117439. Epub 2023 Aug 9. Bioorg Med Chem. 2023. PMID: 37579526 Review.
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and treatment of cerebrovascular disorders and insufficiencies. It has been well documented that antioxidants may contribute to cancer treatment, …
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and t …
Evaluation of vincamine against Acetylcholinesterase enzyme.
Syed Sayeed Ahmad, Khatoon A, Sajid Khan M, Khalid M, Alharbi AM, Siddiqui MH. Syed Sayeed Ahmad, et al. Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):14-21. doi: 10.14715/cmb/2022.68.7.3. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 36495525
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (-3.94 kcal/mol) but with much higher binding energy. ...Thus, the present computational and enzyme kinetics studies conclude that vincamin …
Computationally, it confirmed the interaction between vincamine and AChE at an indistinguishable locus from that of substrate AChI (- …
Vincamine Ameliorates Epithelial-Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis in Rats; Targeting TGF-beta/MAPK/Snai1 Pathway.
Alaaeldin R, Mohyeldin RH, Bekhit AA, Gomaa W, Zhao QL, Fathy M. Alaaeldin R, et al. Molecules. 2023 Jun 9;28(12):4665. doi: 10.3390/molecules28124665. Molecules. 2023. PMID: 37375218 Free PMC article.
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppressed the expression of p53, Bax, TWIST, Snail, and Slug genes as well as the expression of factors such as TGF-beta1, p/t p38 MAPK, p/t ERK1 …
SOD and GPX were also increased following vincamine treatment, while MDA levels were decreased. Additionally, vincamine suppre …
Vincamine as an agonist of G protein-coupled receptor 40 effectively ameliorates pulmonary fibrosis in mice.
Zhao T, Zhou Z, Zhao S, Wan H, Li H, Hou J, Wang J, Qian M, Shen X. Zhao T, et al. Phytomedicine. 2023 Sep;118:154919. doi: 10.1016/j.phymed.2023.154919. Epub 2023 Jun 17. Phytomedicine. 2023. PMID: 37392673
G protein-coupled receptor 40 (GPR40) has been developed as a promising therapeutic target for metabolic disorders and functions potently in varied pathological and physiological processes. Vincamine (Vin) is a monoterpenoid indole alkaloid originated from Madagascar periw …
G protein-coupled receptor 40 (GPR40) has been developed as a promising therapeutic target for metabolic disorders and functions potently in …
Vincamine, a safe natural alkaloid, represents a novel anticancer agent.
Al-Rashed S, Baker A, Ahmad SS, Syed A, Bahkali AH, Elgorban AM, Khan MS. Al-Rashed S, et al. Bioorg Chem. 2021 Feb;107:104626. doi: 10.1016/j.bioorg.2021.104626. Epub 2021 Jan 7. Bioorg Chem. 2021. PMID: 33450545
Vincamine was also found to quench hydroxyl free radicals and deplete iron ions in cancer cells. As a dietary supplement, vincamine is almost non-toxic in BEAS-2B and 3T3-L1 cells. Therefore, we propose that vincamine represents a safe anticancer agent in lun …
Vincamine was also found to quench hydroxyl free radicals and deplete iron ions in cancer cells. As a dietary supplement, vincamin …
Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice.
Xu JW, Xu X, Ling Y, Wang YC, Huang YJ, Yang JZ, Wang JY, Shen X. Xu JW, et al. Acta Pharmacol Sin. 2023 Dec;44(12):2388-2403. doi: 10.1038/s41401-023-01135-1. Epub 2023 Aug 14. Acta Pharmacol Sin. 2023. PMID: 37580494
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ganglion (DRG) neurons, regulating neuropathic pain. We previously have reported that vincamine (Vin), a monoterpenoid indole alkaloid …
G-protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells, but also in spinal dorsal horn and dorsal root ga …
Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids.
Zhang W, Wang Z, Lin G, Xue Y, Wu M, Tang P, Chen F. Zhang W, et al. Org Lett. 2022 Apr 1;24(12):2409-2413. doi: 10.1021/acs.orglett.2c00661. Epub 2022 Mar 21. Org Lett. 2022. PMID: 35312322
Here, we disclose the divergent total syntheses of representative C18-oxo eburnamine-vincamine alkaloids (+)-eburnaminol, (-)-larutenine, and (-)-cuanzine. ...
Here, we disclose the divergent total syntheses of representative C18-oxo eburnamine-vincamine alkaloids (+)-eburnaminol, (-)-laruten …
Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa.
Sim DS, Tang SY, Low YY, Lim SH, Kam TS. Sim DS, et al. Phytochemistry. 2022 Nov;203:113384. doi: 10.1016/j.phytochem.2022.113384. Epub 2022 Aug 23. Phytochemistry. 2022. PMID: 36007666
Thirteen indole alkaloids comprising six vobasine/sarpagine, one vincamine, two voaphylline, two tacaman, one iboga, and one corynantheine alkaloid, were isolated from the leaf extract of Tabernaemontana corymbosa (sample from Taiping, Perak, Malaysia). ...
Thirteen indole alkaloids comprising six vobasine/sarpagine, one vincamine, two voaphylline, two tacaman, one iboga, and one corynant …
Vincamine Alleviates Amyloid-beta 25-35 Peptides-induced Cytotoxicity in PC12 Cells.
Han J, Qu Q, Qiao J, Zhang J. Han J, et al. Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128. doi: 10.4103/0973-1296.196309. Pharmacogn Mag. 2017. PMID: 28216895 Free PMC article.
Western blot detection was carried out to detect the protein expression. RESULTS: Our studies showed that pretreatment with vincamine could reduce Abeta25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, …
Western blot detection was carried out to detect the protein expression. RESULTS: Our studies showed that pretreatment with vincamine …
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice.
Du T, Yang L, Xu X, Shi X, Xu X, Lu J, Lv J, Huang X, Chen J, Wang H, Ye J, Hu L, Shen X. Du T, et al. J Endocrinol. 2019 Feb 1;240(2):195-214. doi: 10.1530/JOE-18-0432. J Endocrinol. 2019. PMID: 30400036
Given the neuronal protection of vincamine and the potency of beta-cell amelioration in treating type 2 diabetes mellitus (T2DM), we investigated the potential of vincamine in protecting beta-cells and ameliorating glucose homeostasis in vitro and in vivo. ...Moreov …
Given the neuronal protection of vincamine and the potency of beta-cell amelioration in treating type 2 diabetes mellitus (T2DM), we …
502 results